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Penetrating abdominal trauma poses significant challenges in clinical practice, often resulting from stabbing incidents. Such injuries frequently involve hollow viscus organs, with the intestines being the most commonly affected. While abdominal vena cava (AVC) injuries are rare, they can have severe consequences. We present a case of a 30-year-old woman who sustained a homicidal abdominal stab injury resulting in stomach perforation and the retention of a knife blade. Limited expertise at the peripheral hospital necessitated referral to our tertiary facility. The patient underwent exploratory laparotomy at the peripheral hospital, where the stomach perforation was repaired, but the retained knife blade was initially overlooked. Subsequent imaging revealed its presence, prompting a referral to our center. Upon admission, computed tomography (CT) imaging confirmed the blade locations within the duodenum's lumen and adjacent to the inferior vena cava (IVC). Elective exploration was planned, leading to successful removal of the blade and repair of associated injuries. Penetrating abdominal trauma requires a systematic approach to investigation and management. Collaboration between surgical specialties and advanced imaging techniques is pivotal in achieving optimal outcomes. This case underscores the complexities of managing penetrating abdominal trauma and the crucial role of collaboration and expertise in ensuring successful outcomes.